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Skin cancer research


Skin cancer (excluding malignant melanoma and basal cell carcinoma) are the second most comon cancers among men and women in Sweden. Skin cancer is also the fastest growing cancer type, its incidence has nearly doubled in the last ten years. Cumulative exposure to ultraviolet light from the sun is the major risk factor and ultimate cause for most cases of skin cancers. Our research is about the understanding of the role of non-coding RNAs, RNAs that have regulatory functions in our cells, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in skin cancer. We study the role of ncRNAs in skin development, the maturation of skin cells, oncogenic transformation and also in their immune response, which has important roles in infection and cancer. We explore the interactions among ncRNAs and transcription factors as well as epigenetic changes in skin cancer. We hope that non-coing RNAs may become therapeutic targets and a novel way to treat skin cancers in the future.


Selected publications

Srivastava A, Nikamo P, Lohcharoenkal W, Li D, Meisgen F, Xu Landén N, Ståhle M, Pivarcsi A, Sonkoly E. MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis. J Allergy Clin Immunol. 2017 Feb;139(2):550-561.

Lohcharoenkal W, Harada M, Lovén J, Meisgen F, Landén NX, Zhang L, Lapins J, Mahapatra KD, Shi H, Nissinen L, Kähäri VM, Ståhle M, Sonkoly E, Grandér D, Arsenian-Henriksson M, Pivarcsi A. MicroRNA-203 Inversely Correlates with Differentiation Grade, Targets c-MYC, and Functions as a Tumor Suppressor in cSCC. J Invest Dermatol. 2016 Dec;136(12):2485-2494. 

Li D, Wang A, Liu X, Meisgen F, Grünler J, Botusan IR, Narayanan S, Erikci E, Li X, Blomqvist L, Du L, Pivarcsi A, Sonkoly E, Chowdhury K, Catrina SB, Ståhle M, Landén NX. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing. J Clin Invest. 2015 Aug 3;125(8):3008-26.

Li D, Li X, Wang A, Meisgen F, Pivarcsi A, Sonkoly E, Ståhle M, Landén NX. MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration. J Invest Dermatol. 2015 Jun;135(6):1676-1685.

Pivarcsi A, Ståhle M, Sonkoly E. Genetic polymorphisms altering microRNA activity in psoriasis--a key to solve the puzzle of missing heritability? Exp Dermatol. 2014 Sep;23(9):620-4.

Villegas VE, Rahman MF, Fernandez-Barrena MG, Diao Y, Liapi E, Sonkoly E, Ståhle M, Pivarcsi A, Annaratone L, Sapino A, Ramírez Clavijo S, Bürglin TR, Shimokawa T, Ramachandran S, Kapranov P, Fernandez-Zapico ME, Zaphiropoulos PG. Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1. Mol Oncol. 2014 Jul;8(5):912-26.

Wang A, Landén NX, Meisgen F, Lohcharoenkal W, Ståhle M, Sonkoly E, Pivarcsi A. MicroRNA-31 is overexpressed in cutaneous squamous cell carcinoma and regulates cell motility and colony formation ability of tumor cells. PLoS One. 2014 Jul 28;9(7):e103206.

Meisgen F, Xu Landén N, Wang A, Réthi B, Bouez C, Zuccolo M, Gueniche A, Ståhle M, Sonkoly E, Breton L, Pivarcsi A. MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes. J Invest Dermatol. 2014 Jul;134(7):1931-1940. 

Gastaldi C, Bertero T, Xu N, Bourget-Ponzio I, Lebrigand K, Fourre S, Popa A, Cardot-Leccia N, Meneguzzi G, Sonkoly E, Pivarcsi A, Mari B, Barbry P, Ponzio G, Rezzonico R. miR-193b/365a cluster controls progression of epidermal squamous cell carcinoma. Carcinogenesis. 2014 May;35(5):1110-20.

Meisgen F, Xu Landén N, Bouez C, Zuccolo M, Gueniche A, Ståhle M, Sonkoly E, Breton L, Pivarcsi A. Activation of toll-like receptors alters the microRNA expression profile of keratinocytes. Exp Dermatol. 2014 Apr;23(4):281-3.

Pivarcsi A, Meisgen F, Xu N, Ståhle M, Sonkoly E. Changes in the level of serum microRNAs in patients with psoriasis after antitumour necrosis factor-α therapy. Br J Dermatol. 2013 Sep;169(3):563-70.

Sääf A, Kockum I, Wahlgren CF, Xu N, Sonkoly E, Ståhle M, Nordenskjöld M, Bradley M, Pivarcsi A. Are BIC (miR-155) polymorphisms associated with eczema susceptibility? Acta Derm Venereol. 2013 May;93(3):366-7. 

Wei TL, Xu N, Meisgen F, Stahle M, Sonkoly E, Pivarcsi A. Interleukin-8 is regulated by miR-203 at the posttranscriptional level in primary human keratinocytes. Eur J Dermatol. 2013 Apr 19 23; 66-71.

Bergman P, James T, Kular L, Ruhrmann S, Kramarova T, Kvist A, Supic G, Gillett A, Pivarcsi A, Jagodic M. Next-generation sequencing identifies microRNAs that associate with pathogenic autoimmune neuroinflammation in rats. J Immunol. 2013 Apr 15;190(8):4066-75.

Xu N, Meisgen F, Butler LM, Han G, Wang XJ, Söderberg-Nauclér C, Ståhle M, Pivarcsi A, Sonkoly E. MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40. J Immunol. 2013 Jan 15;190(2):678-88.

Sääf A, Pivarcsi A, Winge MC, Wahlgren CF, Homey B, Nordenskjöld M, Tengvall-Linder M, Bradley M. Characterization of EGFR and ErbB2 expression in atopic dermatitis patients. Arch Dermatol Res. 2012 Dec;304(10):773-80.

Xu N, Zhang LY, Meisgen F, Harada M, Heilborn J, Homey B, Grander D, Stahle M, Sonkoly E, Pivarcsi A. MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration, and Invasion. J Biol Chem. 2012 Aug 24;287(35):29899-908.

Sonkoly E, Lovén J, Xu N, Meisgen F, Wei T, Brodin P, Jaks V, Kasper M, Shimokawa T, Harada M, Heilborn J, Hedblad MA, Hippe A, Grandér D, Homey B, Zaphiropoulos PG, Arsenian-Henriksson M, Ståhle M, Pivarcsi A. MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma. Oncogenesis. 2012 Mar 12;1:e3.

Fekete T, Szabo A, Beltrame L, Vivar N, Pivarcsi A, Lanyi A, Cavalieri D, Rajnavolgyi E, Rethi B. Constraints for monocyte-derived dendritic cell functions under inflammatory conditions. Eur J Immunol. 2012 Feb;42(2):458-69.

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