Biography
Professor Robert A. Harris
Professor Robert A. Harris (Bob) was born in Harpenden in Southern UK in 1966. He conducted a Bsc.Hons undergraduate degree at Portsmouth Polytechnic, majoring in Parasitology in 1987. PhD studies at University College London studying innate immune agglutinins in Schistosoma host snail species with Terry Preston and Vaughan Southgate as supervisors culminated with a thesis defence in early 1991. A 2.5 year postdoc at the London School of Hygiene & Tropical Medicine in Paul Kaye’s research group ensued, with focus on understanding the intracellular fate of Leishmania spp. protozoans in macrophages. Bob was awarded a Wellcome Trust postdoctoral fellowship that permitted his relocation to the Karolinska Institutet (Stockholm, Sweden) in the spring of 1994. A postdoc period was spent split between the labs of Anders Örn and Tomas Olsson, in which he studied Trypanosoma cruzi and Trypanosoma bruceii protozoan proteins. Bob became an Associate Professor at the Karolinska Institutet in 1999, heralding his establishment as a PI. Bob started to work with autoimmune diseases in 1996 and began study of therapy using live parasite infections or parasite molecules. His research group has developed autoantigen-specific vaccines, defined the effects of post-translational biochemical molecules on autoantigenicity and developed a macrophage adoptive transfer therapy that prevents pathogenesis in several experimental disease models. He became Professor of Immunotherapy in Neurological Diseases in 2013. In recent years research focus has centred on understanding the immunopathogenesis of incurable neurodegenerative diseases, with particular emphasis on development of immunotherapies directed at microglial cells as potential therapeutic paradigms.
Bob Harris CV July 2020
ERIK HERLENIUS GROUP
Development of autonomic control
About
Immature or deficient autonomic control is a common problem in infants born at a premature age and is of central importance in apneas, secondary hypoxic brain damage and sudden infant death syndrome.
PER ERIKSSON GROUP
Cardiovascular Genetics and Genomics
Research
For better understanding of disturbances in respiratory control we study early development of cardiorespiratory control, brainstem neural networks and its associations with normal and pathological breathing. The conceptual change introduced by our recent data that endogenous prostaglandins are central pathogenic factors in respiratory disorders and the hypoxic response, open new diagnostic and therapeutic avenues that should significantly better the diagnostics and treatment of newborns and adult patients.
Inflammation is a major culprit in breathing disorders and we hypothesize that by using a newly developed urinary prostaglandin biomarker we can screen, detect and protect against inflammation related breathing disorders.
Our collaborative efforts enable us to move from a clinical problem to molecular understanding of the disease and studies are performed in patients, animal & in vitro models.
Our research is focused on the development of autonomic control with normal and paediatric patients as the target. Autonomic dysfunction in breathing and circulatory control often has its origin in neurodevelopment disorders. Furthermore, our basic research in developmental neuroscience how neural activity and stem cells form activity dependent networks is vital for the development of therapeutic interventions.
Read more
Contact: communication@cmm.se
CENTER FOR MOLECULAR MEDICINE
Calendar
Upcoming Events
Dissertation
Ali Mahdi
26 November
9:00
Title: The Red Blood Cell as a Mediator of Vascular
Injury in Type 2 Diabetes and COVID-19
Speaker: Ali Mahdi
Opponent:
Professor Charalambos Antoniades, University of Oxford, United Kingdom, Radcliffe Department of Medicine, Division of Cardiovascular Medicine
Main supervisor:
Professor John Pernow, Department of Medicine, Solna, Division of Cardiology
Time and location:
Friday, 26 November 2021 at 09:00
Rolf Luft Auditorium, L1:00, Anna Steckséns gata 53, Karolinska University Hospital, Solna, Sweden
Zoom-link: https://ki-se.zoom.us/j/62990367704?pwd=VWN6ZTFQSS9qZzJWWHBOTjFRUUpQZz09
Faculty Breakfast for CMM Group and Team Leaders
29 November
8:15 - 09:30
Topic: Information on the upcoming CMM Scientific Advisory Board
Location: CMM Lecture Hall
Check in at 08:15
Meeting Start 08:30
Meeting End 09:30
The CVP/CVR and Heart and Vascular Theme Joint Meeting 2021
29-30 November
CMMers Anton Gisterå and Carolina Hagberg, are part of the organizing committee, and invite you to participate in this external event:
WELCOME TO THE CVP/CVR AND HEART AND VASCULAR THEME
JOINT MEETING 2021
NOVEMBER 29-30th
in Sune Bergström's Aula and via Zoom
We are planning for a hybrid meeting, changes may occur according to current Covid-19 recommendations.
To register:
• REGISTRATION DEADLINE IS OCTOBER 24th.
• Register and send abstract to cvp.cvr.thk.2021@gmail.com (Registration
is free of charge)
• Please state your academic position and if you intend to participate in
person or online.
• For short talks and poster presentations, abstracts should be 100-250
words and include author names and affiliations, otherwise any format is
accepted
PRELIMINARY PROGRAM
SPEAKERS FOR SHORT TALKS WILL BE SELECTED FROM ABSTRACTS
Scientific Program 29/11
Welcome
13:00-13.10 Welcome address: Ulf Hedin & John Pernow
Atherosclerosis and Vascular Biology
13:15-13:45 Magnus , Karolinska Institutet
13:45-14:00 Short talk 1
14:00-14.15 Short talk 2
14:15-14:45 David Erlinge, Lund University
14:45-15.15 Coffee break & poster setup
Heart failure and Arrythmia
15:15-15:45 Lars Lund, Karolinska Institutet
15:45-16:00 Short talk 1
16:00-16:15 Short talk 2
16:15-16:45 Kristina Haugaa, University of Oslo
16:45-18:00 Poster session and drinks
Scientific Program 30/11
Diabetes and metabolism
9:00-9:30 Jan Eriksson, Uppsala University
9:30-9:45 Short talk 1
9:45-10.00 Short talk 2
10:00-10:30 Niklas Mejhert, Karolinska Institutet
10:30-11.00 Coffee and mingle
Inflammation in cardiovascular disease
11:00-11:30 Mia Philipsson, Uppsala University
11:30-11:45 Short talk 1
11:44-12:00 Short talk 1
12:30-13.00 TBA
12:30-12.45 Closing remarks
Organizing committee: Anneli Falkevall, Erika Folestad, Cecilia Morgantini, Luise Zeigler, Eva Svenneberg, Anton Gisterå, Carolina Hagberg
CMM Seminar
2 December
12:00 - 13:00
Title: Immune responses targeting therapeutic and endogenous antibodies: characteristics and clinical implications
Speaker: Dr. Theo Rispens
Sanquin Research, Department of Immunopathology, Amsterdam
Hosts:
Associate Professor Caroline Grönwall
Associate Professor Karin Lundberg
Karolinska Institutet
In CMM Lecture Hall and via Zoom
Lunch sandwiches will be offered on a first come-first served basis.
CMM Lecture Hall L8:00, Visionsgatan 18, grund floor
Link: https://ki-se.zoom.us/j/63853415701
Meeting ID: 638 5341 5701
Dissertation
Nicky Dunn
3 December
9:00
Title: Immunogenicity of Biological Therapies; Frequency, Predictability and Clinical Relevance in Chronic Inflammatory Diseases
Speaker: Nicky Dunn
Opponent:
Professor Kristina Lejon, Department of Clinical Microbiology, Umeå University
Main supervisor:
Associate Professor Anna Fogdell-Hahn, Department of Clinical Neuroscience, Karolinska Institutet
Co-supervisors:
Dr Katharina Fink, Department of Clinical Neuroscience, Karolinska Institutet
Adjunct lecturer, Per Marits, Department of Laboratory Medicine, Karolinska Institutet
Dr Nancy Vivar Pomiano, Department of Medicine, Karolinska Institutet
Examination Board:
Docent Charlotte Dahle, Department of Clinical and Experimental Medicine, Linköping University
Adjunct Senior lecturer Magnus Andersson, Department of Clinical Neuroscience, Karolinska Institutet
Docent Lisa Westerberg, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet
Time and location:
Lecture Hall L8:00, Center for Molecular Medicine, Karolinska University Hospital, Visionsgatan 18, 17176 Stockholm, Sweden
Friday, 3 December 2021 at 09:00
Half-Time Seminar Jan Philipp Reising
6 December
14:00
Title: Inspiration and Inflammation in the Breathing Brainstem
Speaker: Jan Philipp Reising
Opponent:
Professor Charalambos Antoniades, University of Oxford, United Kingdom, Radcliffe Department of Medicine, Division of Cardiovascular Medicine
Main supervisor:
Professor Eric Herlenius, Department of Women's and Children's Helath, Karolinska Institutet
Co-supoervisors:
Professor Per Uhlén, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Dr. David Forsberg, Department of Women's and Children's Helath, Karolinska Institutet
Location: Acquired Immunity VIP Meeting Room, floor 5 (L8:05 018), Center for Molecular Medicine (L8-building), Visionsgatan 18, Karolinska University Hospital
Seminars on Translational Neuroimaging
(StratNeuro Lunch Seminar Series)
6 December
12:00
The CMMer Vasco Souza invites you to this external event
Topic: Translational Neuroimaging
Presenters:
Johan Lundström, Department of Clinical Neuroscience, Karolinska Institutet will speak about
"Olfactory imaging as an early biomarker for PD: possibilities and problems"
Daniel Ferreira Padilla, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet will speak about
"Connecting the dots between PD, DLB and AD with neuroimaging techniques"
Host: Eric Westman, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet
Location: Jan-Åke Gustafssonsalen, NEO, Blickagången 16, Karolinska Institutet Campus Flemingsberg
(sandwich and coffee for 30 attendees will be provided!)
Via Zoom: (https://ki-se.zoom.us/j/65475014745?pwd=UktnVzFNZ0RQTWFBZ0RmKzZXNjlpdz09)
Find more information here
Dissertation
Till Seime
9 December
9:00
Title: The Role of Smooth Muscle Cells in Calcification of Atherosclerotic Plaques
Speaker: Till Seime
Opponent:
Jordan D. Miller, Mayo Clinic Rochester, Minnesota, US
Main supervisor:
Professor Ulf Hedin, Department of Molecular Medicine and Surgery, Karolinska Institutet
Co-supervisors:
Ljubica Matic, Department of Molecular Medicine and Surgery, Karolinska Institutet
Leon J. Schurgers, Department of Biochemistry, CARIM, Maastricht, the Netherlands
Chris Reutelingsperger, Department of Biochemistry, CARIM, Maastricht, the Netherlands
Examination Board:
Lars-Arne Haldosén, Karolinska Institutet
Anders Malmström, Lunds Universitet
Sebastian Lewandovski, Karolinska Institutet
Time and location:
Friday, 9 December 2021 at 09:00
Rolf Luft Auditorium, L1:00, Anna Steckséns gata 53, Karolinska University Hospital, Solna, Sweden
CMM Seminar
20 January
12:00 - 13:00
Title: To be announced
Speaker: John D Isaacs, Professor of Rheumatology | Director of Therapeutics North East, Newcastle University Director of Research|Associate Medical Director, Newcastle upon Tyne Hospitals, Deputy Director, NIHR Newcastle Biomedical Research Centre
Hosts: Anna Fogdell-Hahn