Biography
Professor Robert A. Harris
Professor Robert A. Harris (Bob) was born in Harpenden in Southern UK in 1966. He conducted a Bsc.Hons undergraduate degree at Portsmouth Polytechnic, majoring in Parasitology in 1987. PhD studies at University College London studying innate immune agglutinins in Schistosoma host snail species with Terry Preston and Vaughan Southgate as supervisors culminated with a thesis defence in early 1991. A 2.5 year postdoc at the London School of Hygiene & Tropical Medicine in Paul Kaye’s research group ensued, with focus on understanding the intracellular fate of Leishmania spp. protozoans in macrophages. Bob was awarded a Wellcome Trust postdoctoral fellowship that permitted his relocation to the Karolinska Institutet (Stockholm, Sweden) in the spring of 1994. A postdoc period was spent split between the labs of Anders Örn and Tomas Olsson, in which he studied Trypanosoma cruzi and Trypanosoma bruceii protozoan proteins. Bob became an Associate Professor at the Karolinska Institutet in 1999, heralding his establishment as a PI. Bob started to work with autoimmune diseases in 1996 and began study of therapy using live parasite infections or parasite molecules. His research group has developed autoantigen-specific vaccines, defined the effects of post-translational biochemical molecules on autoantigenicity and developed a macrophage adoptive transfer therapy that prevents pathogenesis in several experimental disease models. He became Professor of Immunotherapy in Neurological Diseases in 2013. In recent years research focus has centred on understanding the immunopathogenesis of incurable neurodegenerative diseases, with particular emphasis on development of immunotherapies directed at microglial cells as potential therapeutic paradigms.
Bob Harris CV July 2020
ERIK HERLENIUS GROUP
Development of autonomic control
About
Immature or deficient autonomic control is a common problem in infants born at a premature age and is of central importance in apneas, secondary hypoxic brain damage and sudden infant death syndrome.
PER ERIKSSON GROUP
Cardiovascular Genetics and Genomics
Research
For better understanding of disturbances in respiratory control we study early development of cardiorespiratory control, brainstem neural networks and its associations with normal and pathological breathing. The conceptual change introduced by our recent data that endogenous prostaglandins are central pathogenic factors in respiratory disorders and the hypoxic response, open new diagnostic and therapeutic avenues that should significantly better the diagnostics and treatment of newborns and adult patients.
Inflammation is a major culprit in breathing disorders and we hypothesize that by using a newly developed urinary prostaglandin biomarker we can screen, detect and protect against inflammation related breathing disorders.
Our collaborative efforts enable us to move from a clinical problem to molecular understanding of the disease and studies are performed in patients, animal & in vitro models.
Our research is focused on the development of autonomic control with normal and paediatric patients as the target. Autonomic dysfunction in breathing and circulatory control often has its origin in neurodevelopment disorders. Furthermore, our basic research in developmental neuroscience how neural activity and stem cells form activity dependent networks is vital for the development of therapeutic interventions.
Read more
Contact: communication@cmm.se
CENTER FOR MOLECULAR MEDICINE
Calendar
Upcoming Events
Lecture
11 November
9:00
Title: Uveal Melanoma:Case History of a Mutant GPCR - and Reflections on a Career in Science.
Speaker: Thomas Sakmar
Hosted by CMM Group Leader Per Svenningsson who invites you to this external event.
Honorary Doctor Thomas Sakmar, Visiting Professor of Molecular Biology and Biochemistry at the Department of Neurobiology, Care Sciences and Society (NVS) and active at the Rockefeller University, will give a talk on "Uveal Melanoma:Case History of a Mutant GPCR - and Reflections on a Career in Science.”
Coffee/Tea will be offered.
Location: Karolinska University Hospital, SolnaSune Bergströms aula (J3:07), Bioclinicum, entrance through Solnavägen 30
Dissertation
Henna Salo
12 November
9:00
Title: The Role of the DAMP Molecule HMGB1 in Neuroinflammation and Macrophage Activation
Speaker: Henna Salo
Opponent:
Professor Maria E Johansson
University of Gothenburg
Department of Neuroscience and Physiology
Main supervisor:
Professor Helena Erlandsson Harris, Karolinska Institutet,
Department of Medicine, Solna, Division of Rheumatology
Co-supervisor(s):
Professor Staffan Holmin, Karolinska Institutet
Department of Clinical Neuroscience
Professor Karen Gertz, Charité-Universitätsmedizin
Neurological clinic
Examination Board:
Associate Professor Cesare Patrone, Karolinska Institutet
Department of Clinical Science and Education
Associate Professor Anna Fogdell-Hahn
Karolinska Institutet
Department of Clinical Neuroscience
Professor Maria Lerm, Linköping University
Department of Biomedical and Clinical Sciences
The thesis will be defended in public at CMM Lecture Hall, Visionsgatan 18, (L8:00, Karolinska University Hospital, Solna),
Dissertation
Zelong Dou
12 November
9:00
Title: The Role of the Microenvironment in Growth Plate and Articular Chondrocyte Differentiation
Speaker: Zelong Dou
Opponent: Professor Andrea Vortkamp, University of Duisburg-Essen, Duisburg, Germany, Department of Medical Biotechnology
Main supervisor: Ola Nilsson, Karolinska Institutet and Örebro University
Rolf Luft Auditorium L1:00
Core Facility Seminar
17 November
13:00 - 16:00
Title: Spatial biology and multiplex expression analysis possibilities at KIgene core facility
Schedule
13.00-14:00 The possibilities with nCounter digital counting for bulk multiplex expression analysis
14:00 -14:30 Coffee break
14:30-16:00 The possibilities within spatial proteomics and transcriptomics with the GeoMX platform
Venue: Campus Solna, Biomedicum, Ragnar Granit
Please register for parts or the whole seminar via email to ida.nilsson@ki.se
CMM Seminar
18 November
12:00 - 13:00
Title: Update on SARS-CoV-2 and Covid-19
Speaker: Jan Albert, Professor, MD, Dept of Microbiology, Tumor and Cell Biology, Karolinska Institutet Dept of Clinical Microbiology, Karolinska University Hospital
Host: Anna Fogdell-Hahn, Docent, Karolinska Institutet, Dept of Clinical Neuroscience
Dissertation
Philip Curman
19 November
9:00
Title: Darier disease: more than skin deep
Speaker: Philip Curman
Opponent:
Professor Sirkku Peltonen, Department of Dermatology and Venereology, University of Gothenburg
Main supervisor:
Associate professor Jakob Wikström, Department of Medicine Solna,
Division of Dermatology and Venereology, Karolinska Institutet
Co-supervisor(s):
Associate professor Enikö Sonkoly, Department of Medicine Solna, Division of Dermatology and Venereology, Karolinska Institutet
Martin Cederlöf, PhD, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
Examination Board:
Professor emeritus Chris Anderson, Department of Biomedical and Clinical Sciences, Division of Cell Biology, Linköping University
Associate professor Desiree Wiegleb Edström, Department of Medical Sciences, Örebro University
Professor emeritus Klas Nordlind, Department of Medicine Solna, Division of Dermatology and Venereology, Karolinska Institutet
Time and location:
Lecture Hall L8:00, Center for Molecular Medicine, Visionsgatan 18, 17176 Stockholm, Sweden
Friday, 19 November 2021 at 09:00
Zoom-link:
https://ki-se.zoom.us/j/68982856543
The CVP/CVR and Heart and Vascular Theme Joint Meeting 2021
29-30 November
CMMers Anton Gisterå and Carolina Hagberg, are part of the organizing committee, and invite you to participate in this external event:
WELCOME TO THE CVP/CVR AND HEART AND VASCULAR THEME
JOINT MEETING 2021
NOVEMBER 29-30th
in Sune Bergström's Aula and via Zoom
We are planning for a hybrid meeting, changes may occur according to current Covid-19 recommendations.
To register:
• REGISTRATION DEADLINE IS OCTOBER 24th.
• Register and send abstract to cvp.cvr.thk.2021@gmail.com (Registration
is free of charge)
• Please state your academic position and if you intend to participate in
person or online.
• For short talks and poster presentations, abstracts should be 100-250
words and include author names and affiliations, otherwise any format is
accepted
PRELIMINARY PROGRAM
SPEAKERS FOR SHORT TALKS WILL BE SELECTED FROM ABSTRACTS
Scientific Program 29/11
Welcome
13:00-13.10 Welcome address: Ulf Hedin & John Pernow
Atherosclerosis and Vascular Biology
13:15-13:45 Magnus , Karolinska Institutet
13:45-14:00 Short talk 1
14:00-14.15 Short talk 2
14:15-14:45 David Erlinge, Lund University
14:45-15.15 Coffee break & poster setup
Heart failure and Arrythmia
15:15-15:45 Lars Lund, Karolinska Institutet
15:45-16:00 Short talk 1
16:00-16:15 Short talk 2
16:15-16:45 Kristina Haugaa, University of Oslo
16:45-18:00 Poster session and drinks
Scientific Program 30/11
Diabetes and metabolism
9:00-9:30 Jan Eriksson, Uppsala University
9:30-9:45 Short talk 1
9:45-10.00 Short talk 2
10:00-10:30 Niklas Mejhert, Karolinska Institutet
10:30-11.00 Coffee and mingle
Inflammation in cardiovascular disease
11:00-11:30 Mia Philipsson, Uppsala University
11:30-11:45 Short talk 1
11:44-12:00 Short talk 1
12:30-13.00 TBA
12:30-12.45 Closing remarks
Organizing committee: Anneli Falkevall, Erika Folestad, Cecilia Morgantini, Luise Zeigler, Eva Svenneberg, Anton Gisterå, Carolina Hagberg