Biography
Professor Robert A. Harris
Professor Robert A. Harris (Bob) was born in Harpenden in Southern UK in 1966. He conducted a Bsc.Hons undergraduate degree at Portsmouth Polytechnic, majoring in Parasitology in 1987. PhD studies at University College London studying innate immune agglutinins in Schistosoma host snail species with Terry Preston and Vaughan Southgate as supervisors culminated with a thesis defence in early 1991. A 2.5 year postdoc at the London School of Hygiene & Tropical Medicine in Paul Kaye’s research group ensued, with focus on understanding the intracellular fate of Leishmania spp. protozoans in macrophages. Bob was awarded a Wellcome Trust postdoctoral fellowship that permitted his relocation to the Karolinska Institutet (Stockholm, Sweden) in the spring of 1994. A postdoc period was spent split between the labs of Anders Örn and Tomas Olsson, in which he studied Trypanosoma cruzi and Trypanosoma bruceii protozoan proteins. Bob became an Associate Professor at the Karolinska Institutet in 1999, heralding his establishment as a PI. Bob started to work with autoimmune diseases in 1996 and began study of therapy using live parasite infections or parasite molecules. His research group has developed autoantigen-specific vaccines, defined the effects of post-translational biochemical molecules on autoantigenicity and developed a macrophage adoptive transfer therapy that prevents pathogenesis in several experimental disease models. He became Professor of Immunotherapy in Neurological Diseases in 2013. In recent years research focus has centred on understanding the immunopathogenesis of incurable neurodegenerative diseases, with particular emphasis on development of immunotherapies directed at microglial cells as potential therapeutic paradigms.
Bob Harris CV July 2020
ERIK HERLENIUS GROUP
Development of autonomic control
About
Immature or deficient autonomic control is a common problem in infants born at a premature age and is of central importance in apneas, secondary hypoxic brain damage and sudden infant death syndrome.
PER ERIKSSON GROUP
Research
For better understanding of disturbances in respiratory control we study early development of cardiorespiratory control, brainstem neural networks and its associations with normal and pathological breathing. The conceptual change introduced by our recent data that endogenous prostaglandins are central pathogenic factors in respiratory disorders and the hypoxic response, open new diagnostic and therapeutic avenues that should significantly better the diagnostics and treatment of newborns and adult patients.
Inflammation is a major culprit in breathing disorders and we hypothesize that by using a newly developed urinary prostaglandin biomarker we can screen, detect and protect against inflammation related breathing disorders.
Our collaborative efforts enable us to move from a clinical problem to molecular understanding of the disease and studies are performed in patients, animal & in vitro models.
Our research is focused on the development of autonomic control with normal and paediatric patients as the target. Autonomic dysfunction in breathing and circulatory control often has its origin in neurodevelopment disorders. Furthermore, our basic research in developmental neuroscience how neural activity and stem cells form activity dependent networks is vital for the development of therapeutic interventions.
Read more
Contact: communication@cmm.se
CENTER FOR MOLECULAR MEDICINE
Calendar
Upcoming Events
Thursday 2 February
15:30
Clinical Seminar
CMMer Ioannis Parodis invites you to this seminr focused on clinical rheumatology.
Title: Imaging in Connective Tissue Diseases organ involvement: What is new?
Speaker: Annamaria Iagnocco
Annamaria Iagnocco (EULAR president) is here for Yogan Kisten’s dissertation on Friday 3 February at 09:00.
Location:
CMM Lecture Hall, L8:00
Friday 3 February
09:00
Dissertation
Yogan Kisten
Welcome to Yogan Kisten's dissertation.
Title: Ultrasound and Fluorescence Optical Imaging Biomarkers for Early Diagnosis and Prediction of Rheumatoid Arthritis
Speaker: Yogan Kisten
Opponent
Prof. Annamaria lagnocco
University of Turin, Department of Clinical and Biological Science, Academic Rheumatology Centre, Turin, Italy.
Principal supervisor
Prof. Lars Klareskog
Karolinska lnstitutet, Department of Medicine, Solna, Division of Rheumatology.
Co-supervisors
Dr. Aase Hensvold
Karolinska lnstitutet, Department of Medicine, Solna, Division of Rheumatology.
Dr. Hamed Rezaei
Karolinska lnstitutet, Department of Medicine, Solna, Division of Rheumatology.
Examination Board
Prof. Hans Carlsten
University of Goteborg, Institute of Medicine, Department of Rheumatology and Inflammation Research, Goteborg.
Ass. Prof. Anna-Karin Hultgard Ekwall
University of Goteborg, Institute of Medicine, Department of Rheumatology and Inflammation Research, Goteborg.
Ass. Prof. Anna Fogdell-Hahn
Karolinska lnstitutet, Department of Clinical Neuroscience, Solna.
Location:
CMM Lecture Hall, Visionsgatan 18, ground floor, L8 00
Zoom link
https://ki-se.zoom.us/j/66872412110?pwd=OERBMnRqV3AwMzl2UkRZMzRzaVlhUT09
Meeting ID: 668 7241 2110
Passcode: 115360
KI-calendar Link
Monday 6 February
12:00 - 13:00
StratNeuro
Lunch Seminar
(external)
CMMer Vasco Sousa invites you to this event.
Tuesday 7 February
09:30
Half-time Seminar
Iman Shryki
Welcome to Iman Shryki's half-time seminar:
Title: Development, function and relevance of CD8 T cell subsets in anti-tumour immunity
Speaker: Iman Shryki
Principal supervisor
Carmen Gerlach
Co-supervisors
Fredrik Wermeling
Mikael Karlsson
Half-time review board
Marcus Buggert
Susanne Gabrielsson
Vivianne Malmström
Location:
CMM L803:021, Macrophage room, & virtually
Thursday 9 February
12:00-13:00
CMM Seminar
Welcome to CMM Seminar on Thursday 2023-02-09 at 12.00-13.00 in CMM Lecture Hall and online via Zoom.
Lunch sandwiches will be offered from 12.00, on a first come-first served basis.
Title: CAR T cells produced in vivo to treat cardiac injury
Speaker: Joel Ruric, Perelman School of Medicine at the University of Pennsylvania
Host: Eduardo Villablanca, Karolinska Institutet, Department of Medicine, Solna
Venue: CMM Lecture Hall, Visionsgatan 18, ground floor and online via zoom
Zoom link:
https://ki-se.zoom.us/j/61410698345?pwd=TjZSUWFlUExIcTRyb2x0K1FJMXRxQT09
Meeting ID: 614 1069 8345
Passcode: 391511
Thursday 16 February
12:00-13:00
CMM Seminar
Welcome to CMM Seminar on Thursday 2023-02-16 at 12.00-13.00 in CMM Lecture Hall and online via Zoom.
Lunch sandwiches will be offered from 12.00, on a first come-first served basis.
Title:The Many Flavours of ACPA: from pathogenic to anti-inflammatory effects
Speaker: Bruno Raposo, PhD, Senior Researcher at Karolinska Institutet, Department of Medicine, Solna, Division of Rheumatology, Center for Molecular Medicine
Host: Vivianne Malmström, Professor at Karolinska Institute, Department of Medicine, Solna, Division of Rheumatology, Center for Molecular Medicine
Venue: CMM Lecture Hall, Visionsgatan 18, ground floor and online via zoom