Exploring the role and therapeutic potential of non-coding RNAs in chronic skin inflammation
Skin is our largest organ, representing an interface between the organism and the environment. The uppermost part of the skin, the epidermis is a continuously renewing tissue governed by a tightly regulated differentiation program. Being much more than just a physical barrier, the epidermis is a complex immunological barrier that can recognize and respond to external stimuli including pathogens.
Psoriasis and atopic dermatitis are the most common chronic inflammatory skin diseases, and they have a significant impact on the quality of life of the affected patients. In these chronic inflammatory skin diseases, activation of the immune system in interaction with keratinocytes, the main cell type in the epidermis, sustains chronic inflammation.
Non-coding RNAs, constituting a large part of transcriptional output in our cells, have important regulatory functions in the cells. Both short (e.g. miRNAs) and long (long non-coding RNAs, lncRNAs) have emerged as important gene regulators in health and disease.
Our research aims to explore how non-coding RNAs contribute to chronic inflammatory skin diseases, and their potential as biomarkers and therapy targets. For this, we use patient samples, cell culture, 3D epidermal models and animal models of skin inflammation. We have identified several miRNAs that regulate crucial cellular functions in psoriasis and their modulation affects skin inflammation in preclinical models.
Exploring the function of non-coding RNAs in skin diseases also sheds light on their functions in the complex regulatory networks that ensure proper epidermal differentiation and immune responses but prevent excessive inflammation in normal skin.
National Psoriasis Foundation (USA), Discovery Grant, 75000 USD, 2019-2021
ALF Medicine Project Grant, 1.500.000 SEK, 2019-2021
KID Grant, 50% support for a PhD student 2021- (to be recruited)
Swedish Research Council, Half-time Position in Clinical Research Environment, 1 850 000 SEK/ year 2016-2018
ALF Medicine project grant, 929 000 SEK, 2016-2017
KID grant for Ankit Srivastava (2014-2018) and Lorenzo Pasquali (2016-2020)
Åke Wibergs Foundation, 300 000 SEK, 2015
Inflammation Europe ASPIRE 2014 research award (Pfizer), 515 221 SEK, 2015
The Swedish Skin Foundation, 800 000 SEK, 2015-2016
Psoriasisförbundet, 150 000 kr, 2015-2016
KI Research Foundation, 27 600 SEK, 2014-2015
Psoriasisförbundet, 150 000 SEK, 2013
National Psoriasis Foundation (USA), 200 000 USD, 2012-2014
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