HANNA BRAUNER TEAM

About

The overall goal with our research is to study the pathogenic mechanisms leading to lymphoma and autoimmunity, and factors controlling disease progression. The ultimate aim is to improve diagnosis, monitoring the disease and improving treatment of these patients. 

Our laboratory at the Centre for Molecular Medicine (CMM) is strategically placed close to the Karolinska University hospital, enabling easy access of clinical samples. We use a broad array of advanced laboratory techniques, including in vitroand ex vivoassays of cellular immunology, cell biology and genetic analysis, to investigate unique clinical material and perform registry studies.We have a strong collaborative team with clinicians and researchers in dermatology, rheumatology, hematology, pathology, immunology and epidemiology. 

The research is clearly translational, bridging from patients to basic science and back to the patients again, with the scientific questions always originating in the clinical disease. 

 

We are always looking for highly motivated people to join our team. Please contact Hanna Brauner if you are interested, at hanna.brauner@ki.se

 

Biography

Hanna Brauner

I am currently researcher and team leader at Centre for Molecular Medicine (CMM), the Department of Medicine, Solna and physician at the Dermatology clinic, Karolinska University hospital. I defended my thesis in 2010, at the Department of Microbiology, Tumor and Cell biology, Karolinska Institutet (KI), supervised by professors Petter Höglund and Klas Kärre. My first postdoctoral training was with professor James Di Santo, the Pasteur Institute, in 2012-2013. Thereafter I did a second postdoctoral period with associate professor Lisa Westerberg, KI, in 2015-2017. In 2018 I was awarded a young investigator award from the Swedish Society for Medical Research (SSMF) and was recruited to the Department of Medicine, Solna and CMM to continue to develop my research within the field of autoimmunity and lymphoma.

 

Funding

Swedish Society for Medical Research (SSMF), Young Investigator Award

Åke Wiberg Foundation 

Clas Groschinsky Memorial Fondation

KI Fonds

KI Foundation Grants for Rheumatology Research

 

Media

Hanna Brauner och Marco Gerling får SSMF:s stora forskningsanslag

Svenska Sällskapet för Medicinsk Forskning

Forskarnas nyheter: Åtta ovanligt lovande forskare premieras med 48 miljoner

 

Selected publications

Keszei M, Record J, Kritikou JS, Wurzer H, Geyer C, Thiemann M, Drescher P, Brauner H, Köcher L, James J, He M, Baptista MA, Dahlberg CI, Biswas A, Lain S, Lane DP, Song W, Pütsep K, Vandenberghe P, Snapper SB, Westerberg LS. Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactiveJ Clin Invest. 2018 Aug 31;128(9):4115-4131.

Kritikou JS, DahlbergCIM, Baptista  MAP, Wagner AK, Banerjee PP, Gwalani LA, Poli C, Panda S, Kärre K, Kaech SM, Wermeling F, Andersson J, Orange JS, Brauner H,Westerberg LS. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Sci Rep. 2016 Aug 1. 

Wagner AK, Wickström SL, Tallerico R, Salam S, Lakshmikanth T, Brauner H, Höglund P, Carbone E, Johansson MH, Kärre K. Retuning of Mouse NK Cells after Interference with MHC Class I Sensing Adjusts Self-Tolerance but Preserves Anticancer Response. Cancer Immunol Res. 2016 Feb;4(2):113-23. 

Brauner H, Hall HT, Flodström-Tullberg M, Kärre K, Höglund P, Johansson S. Depletion of IL-2 receptor β-positive cells protects from diabetes in non-obese diabetic mice. Immunol Cell Biol. 2016 Feb;94(2):177-84.

Brauner H, Lüthje P, Grünler J, Ekberg NR, Dallner G, Brismar K, Brauner A. Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q10 on inflammatory activity. Clin Exp Immunol.2014 Aug;177(2):478-82. 

Lüthje P, Brauner H, Ramos NL, Ovregaard A, Gläser R, Hirschberg AL, Aspenström P, Brauner A. Estrogen supports urothelial defense mechanisms. Sci Transl Med. 2013 Jun 19;5(190):190ra80.

Hertting O, Holm Å, Lüthje P, Brauner H, Dyrdak R, Jonasson AF, Wiklund P, Chromek M, Brauner A. Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. PLoS One. 2010 Dec 14;5(12):e15580.

Brauner H, Elemans M, Lemos S, Broberger C, Holmberg D, Flodström-Tullberg M, Kärre K, Höglund P. Distinct phenotype and function of NK cells in the pancreas of nonobese diabetic mice. J Immunol.2010 Mar 1;184(5):2272-80. 

Foo KS*, Brauner H*, Ostenson CG, Broberger C. Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state. J Endocrinol.2010 Mar;204(3):255-63. *shared first author

Lindh E, Rosmaraki E, Berg L, Brauner H, Karlsson MC, Peltonen L, Höglund P, Winqvist O. AIRE deficiency leads to impaired iNKT cell development. J Autoimmun.2010 Feb;34(1):66-72. 

Hall HT*, Sjölin H*, Brauner H, Tomasello E, Dalod M, Vivier E, Höglund P. Increased diabetes development and decreased function of CD4+CD25+ Treg in the absence of a functional DAP12 adaptor protein. Eur J Immunol. 2008 Nov;38(11):3191-9. *shared first author