Professor Robert A. Harris
Professor Robert A. Harris (Bob) was born in Harpenden in Southern UK in 1966. He conducted a Bsc.Hons undergraduate degree at Portsmouth Polytechnic, majoring in Parasitology in 1987. PhD studies at University College London studying innate immune agglutinins in Schistosoma host snail species with Terry Preston and Vaughan Southgate as supervisors culminated with a thesis defence in early 1991. A 2.5 year postdoc at the London School of Hygiene & Tropical Medicine in Paul Kaye’s research group ensued, with focus on understanding the intracellular fate of Leishmania spp. protozoans in macrophages. Bob was awarded a Wellcome Trust postdoctoral fellowship that permitted his relocation to the Karolinska Institutet (Stockholm, Sweden) in the spring of 1994. A postdoc period was spent split between the labs of Anders Örn and Tomas Olsson, in which he studied Trypanosoma cruzi and Trypanosoma bruceii protozoan proteins. Bob became an Associate Professor at the Karolinska Institutet in 1999, heralding his establishment as a PI. Bob started to work with autoimmune diseases in 1996 and began study of therapy using live parasite infections or parasite molecules. His research group has developed autoantigen-specific vaccines, defined the effects of post-translational biochemical molecules on autoantigenicity and developed a macrophage adoptive transfer therapy that prevents pathogenesis in several experimental disease models. He became Professor of Immunotherapy in Neurological Diseases in 2013. In recent years research focus has centred on understanding the immunopathogenesis of incurable neurodegenerative diseases, with particular emphasis on development of immunotherapies directed at microglial cells as potential therapeutic paradigms.
Bob Harris CV July 2020
ERIK HERLENIUS GROUP
Development of autonomic control
Immature or deficient autonomic control is a common problem in infants born at a premature age and is of central importance in apneas, secondary hypoxic brain damage and sudden infant death syndrome.
PER ERIKSSON GROUP
For better understanding of disturbances in respiratory control we study early development of cardiorespiratory control, brainstem neural networks and its associations with normal and pathological breathing. The conceptual change introduced by our recent data that endogenous prostaglandins are central pathogenic factors in respiratory disorders and the hypoxic response, open new diagnostic and therapeutic avenues that should significantly better the diagnostics and treatment of newborns and adult patients.
Inflammation is a major culprit in breathing disorders and we hypothesize that by using a newly developed urinary prostaglandin biomarker we can screen, detect and protect against inflammation related breathing disorders.
Our collaborative efforts enable us to move from a clinical problem to molecular understanding of the disease and studies are performed in patients, animal & in vitro models.
Our research is focused on the development of autonomic control with normal and paediatric patients as the target. Autonomic dysfunction in breathing and circulatory control often has its origin in neurodevelopment disorders. Furthermore, our basic research in developmental neuroscience how neural activity and stem cells form activity dependent networks is vital for the development of therapeutic interventions.
CENTER FOR MOLECULAR MEDICINE
Liv Eidsmo at Copenhagen Lab
Academic Honors, Awards and Prices
LIV EIDSMO GROUP
The Eidsmo laboratory explores mechanisms that dictate the fine-tuned balance between health and focal immunopathology in human skin. The skin barrier is constantly exposed to colonizing microbiota, invasive pathogens, and allergens and immune cells interacts with stroma to protect against microbial invasion. Additionally, the immune system is heavily implicated in common patchy inflammatory diseases such as vitiligo and psoriasis. In healthy skin, the Eidsmo laboratory defined functionally distinct subsets of tissue resident memory T (Trm) cells based on their expression of the integrin CD49a. In diseases such as vitiligo and psoriasis, different subsets of pathogenic Trm cells form localized disease memories in resolved skin.
Right now we focus on how human Trm cells are formed and how these cells impact on their immediate environment. Ultimately, we want to normalise the Trm cell compartment in diseased skin to reach robust and long-term homeostasis.
To be updated
Graduated from medical school 1999 and defended my PhD in Immunobiology at Karolinska Instituet 2006.
Postdoc in Frank Carbone's laboratory at Melbourne University in Australia 2007-09.
Returned to Sweden to build the Eidsmo laboratory at CMM in parallel to clinical training in Dermatology and Venerology at Karolinska University Hospital in 2010.
Board certified Dermatologist in 2017 and since 2019 a Dermatologist at Diagnostiskt Centrum Hud, Stockholm.
Associate Professor in Dermatology and Venereology at Karolinska Institutet 2014.
Professor in Translational Skin Immunology at Copenhagen University from 2021.
The Eidsmo laboratory will be placed at CMM Karolinska Institutet and at the Leo Foundation Skin Immunology Center at Copenhagen University from 2021.
Liv Eidsmo Lab at Copenhagen Uni
To be updated
Academic Honors, Awards and Prizes
2017 Ellis and Ivar Janzons prize, The Swedish Society of Medicine
2016 Marcus and Marianne Wallenberg Clinical Research Fellow
2014 Ragnar Söderberg Research Fellow
2013 The Dermatology Prize, awarded by the Swedish Society of Dermato-Venerology (SSDV) and Novartis
2010 The Psoriasis Prize, awarded by SSDV and MSD2009 Young Investigator Award, The Karolinska Institutet’s Foundation.
2006 Elected as Honorary Speaker during the Karolinska Institutet's Official PhD Ceremonies.
Koguchi-Yoshioka H, Hoffer E, Cheuk S, Matsumura, Vo S, Kjellman P, Grema L, Ishitsuka Y, Nakamura Y, Okiyama N, Fujisawa Y, Fujimoto F, Eidsmo L†, Clark RA†, Watanabe R†. Human T cells remain diverse and highly functional in the aged skin. Communications Biology, In Press †Shared senior authors.
Gallais Sérézal I, Hoffer E, Ignatov B, Martini E, Zitti B, Ehrström M, Eidsmo L. A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional skin from patients with psoriasis. The Journal of allergy and clinical immunology 2019 143;4 1444-1454
Schulz A, Jiang L, de Vor L, Ehrström M, Wermeling F, Eidsmo L, Melican K. Neutrophil Recruitment to Noninvasive MRSA at the Stratum Corneum of Human Skin Mediates Transient Colonization. Cell reports 2019 29;5 1074-1081.e5
Gallais Sérézal I, Classon C, Cheuk S, Barrientos-Somarribas M, Wadman E, Martini E, Chang D, Xu Landén N, Ehrström M, Nylén S, Eidsmo L. Resident T Cells in Resolved Psoriasis Steer Tissue Responses that Stratify Clinical Outcome. The Journal of investigative dermatology 2018 138;8 1754-1763
Cheuk S, Schlums H, Gallais Sérézal I, Martini E, Chiang SC, Marquardt N, Gibbs A, Detlofsson E, Introini A, Forkel M, Höög C, Tjernlund A, Michaëlsson J, Folkersen L, Mjösberg J, Blomqvist L, Ehrström M, Ståhle M, Bryceson YT, Eidsmo L. CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin. Immunity 2017 46;2 287-300
Martini E, Wikén M, Cheuk S, Gallais Sérézal I, Baharom F, Ståhle M, Smed-Sörensen A, Eidsmo L. Dynamic Changes in Resident and Infiltrating Epidermal Dendritic Cells in Active and Resolved Psoriasis. The Journal of investigative dermatology 2017 137;4 865-873
Cheuk S, Wikén M, Blomqvist L, Nylén S, Talme T, Ståhle M, Eidsmo L. Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis. Journal of immunology (Baltimore, Md. : 1950) 2014 192;7 3111-20
Eidsmo L, Stock AT, Heath WR, Bedoui S, Carbone FR. Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics. Journal of Pathology 2012 226;5 806-13
Eidsmo L, Allan R, Caminschi I, van Rooijen N, Heath WR, Carbone FR. Differential Migration of Epidermal and Dermal Dendritic Cells during Skin Infection. Journal of Immunology 2009 182;5 3165-72
Gebhardt T, Wakim LM, Eidsmo L, Reading PC, Heath WR, Carbone FR. Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nature Immunology 2009 10;5 524-30
Eidsmo L, Martini E. Human Langerhans Cells with Pro-inflammatory Features Relocate within Psoriasis Lesions. Frontiers in immunology 2018 9; 300-
Nylen S, Eidsmo L. Tissue damage and immunity in cutaneous leishmaniasis. Parasite Immunology 2012 34;12 551-61
Eidsmo L, Gerlach C. Heavy Water Shedding Light on Antigen-Specific T Cell Responses. Trends in Immunology 2018 39;3 170-172
Cheuk S, Eidsmo L. The Skinny on Fat Trm Cells. Immunity 2017 47;6 1012-1014