LIV EIDSMO GROUP

 

About

The Eidsmo laboratory explores mechanisms that dictate the fine-tuned balance between health and focal immunopathology in human skin. The skin barrier is constantly exposed to colonizing microbiota, invasive pathogens, and allergens and immune cells interacts with stroma to protect against microbial invasion. Additionally, the immune system is heavily implicated in common patchy inflammatory diseases such as vitiligo and psoriasis. In healthy skin, the Eidsmo laboratory defined functionally distinct subsets of tissue resident memory T (Trm) cells based on their expression of the integrin CD49a. In diseases such as vitiligo and psoriasis, different subsets of pathogenic Trm cells form localized disease memories in resolved skin.

Right now we focus on how human Trm cells are formed and how these cells impact on their immediate environment. Ultimately, we want to normalise the Trm cell compartment in diseased skin to reach robust and long-term homeostasis. 

 

Research

To be updated

Biography

Liv Eidsmo

Graduated from medical school 1999 and defended my PhD in Immunobiology at Karolinska Instituet 2006.

Postdoc in Frank Carbone's laboratory at Melbourne University in Australia 2007-09.

Returned to Sweden to build the Eidsmo laboratory at CMM in parallel to clinical training in Dermatology and Venerology at Karolinska University Hospital in 2010. 

Board certified Dermatologist in 2017 and since 2019 a Dermatologist at Diagnostiskt Centrum Hud, Stockholm.

Associate Professor in Dermatology and Venereology at Karolinska Institutet 2014.

Professor in Translational Skin Immunology at Copenhagen University from 2021.

The Eidsmo laboratory will be placed at CMM Karolinska Institutet and at the Leo Foundation Skin Immunology Center at Copenhagen University from 2021.  

 
 
 

Liv Eidsmo Lab at Copenhagen Uni

To be updated

 

Academic Honors, Awards and Prizes

2017    Ellis and Ivar Janzons prize, The Swedish Society of Medicine

2016    Marcus and Marianne Wallenberg Clinical Research Fellow

2014    Ragnar Söderberg Research Fellow

2013    The Dermatology Prize, awarded by the Swedish Society of Dermato-Venerology  (SSDV) and Novartis

2010    The Psoriasis Prize, awarded by SSDV and MSD2009      Young Investigator Award, The Karolinska Institutet’s Foundation.

2006    Elected as Honorary Speaker during the Karolinska Institutet's Official PhD Ceremonies.

 
Selected Publications

Costantino S, Paneni F, Virdis A, Hussain S, Mohammed SA, Capretti G, Akhmedov A, Dalgaard K, Chiandotto S, Pospisilik JA, Jenuwein T, Giorgio M, Volpe M, Taddei S, Lüscher TF, Cosentino F. Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity. Eur Heart J. 2019 Jan 21;40(4):383-391.

Costantino S, Paneni F, Battista R, Castello L, Capretti G, Chiandotto S, Tanese L, Russo G, Pitocco D, Lanza GA, Volpe M, Lüscher TF, Cosentino F.  Impact of glycemic variability on chromatin remodeling, oxidative stress, and endothelial dysfunction in patients with type 2 diabetes and with target HbA1c levels. 2017 Sep;66(9):2472-2482.

Morici N, Savonitto S, Ponticelli C, Schrieks IC, Nozza A, Cosentino F, Stähli BE, Perrone Filardi P, Schwartz GG, Mellbin L, Lincoff AM, Tardif JC, Grobbee DE. Post-discharge worsening renal function in patients with type 2 diabetes and recent acute coronary syndrome. Am J Med. 2017 Sep;130(9):1068-1075.

Paneni F, Costantino S, Kränkel N, Cosentino F, Lüscher TF. Reprogramming ageing and longevity genes restores paracrine angiogenic properties of early outgrowth cells. Eur Heart J. 2016 Jun 7;37(22):1733-7.

Costantino S, Paneni F, Lüscher TF, Cosentino F. MicroRNA profiling unveils hyperglycaemic memory in the diabetic heart. Eur Heart J. 2016 Feb 7;37(6):572-6.

Costantino S, Paneni F, Lüscher TF, Cosentino F. Pin1 inhibitor Juglone prevents diabetic vascular dysfunction. Int J Cardiol. 2016 Jan 15;203:702-7.

Paneni F, Costantino S, Battista R, Castello L, Capretti G, Chiandotto S, Scavone G, Villano A, Pitocco D, Lanza G, Volpe M, Lüscher TF, Cosentino F. Adverse Epigenetic Signatures by Histone Methyltransferase Set7 Contribute to Vascular Dysfunction in Patients with Type 2 Diabetes. Circ Cardiovasc Genet. 2015 Feb;8(1):150-8.

Paneni F, Costantino S, Castello L, Battista R, Capretti G, Chiandotto S, D’Amario D, Scavone G, Villano A, Rustighi A, Crea F, Pitocco D, Lanza G, Volpe M, Del Sal G, Lüscher TF, Cosentino F. Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes. Eur Heart J. 2015 Apr 1;36(13):817-28.

Angeloni E, Paneni F, Landmesser U, Benedetto U, Melina G, Lüscher TF, Volpe M, Sinatra R, Cosentino F. Lack of protective role of HDL-C in patients with coronary artery disease undergoing elective coronary artery bypass grafting. Eur Heart J. 2013 Dec;34(46):3557-62.

Rydén L, Grant PJ, Anker SD, Berne C, Cosentino F, et al. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J. 2013 Oct;34(39):3035-87.

Paneni F, Osto E, Costantino S, Mateescu B, Briand S, Coppolino G, Perna E, Mocharla P, Akhmedov A, Kubant R, Rohrer L, Malinski T, Camici GG, Matter CM, Mechta-Grigoriou F, Volpe M, Lüscher TF, Cosentino F. Deletion of the activated protein-1 transcription factor JunD induces oxidative stress and accelerates age-related endothelial dysfunction. Circulation. 2013 Mar 19;127(11):1229-40.

Paneni F, Mocharla P, Akhmedov A, Costantino S, Osto E, Volpe M, Lüscher TF,  Cosentino F. Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes. Circ Res. 2012 Jul 20;111(3):278-89.

Ghiadoni L, Faita F, Salvetti M, Cordiano C, Biggi A, Puato M, Di Monaco A, De Siati L, Volpe M, Ambrosio G, Gemignani V, Muiesan ML, Taddei S, Lanza GA, Cosentino F. Assessment of flow-mediated dilation reproducibility: a nationwide multicenter study. J Hypertens. 2012 Jul;30(7):1399-405.

Cosentino F, Battista R, Scuteri A, De Sensi F, De Siati L, Di Russo C, Camici GG, Volpe M. Impact of fasting glycemia and regional cerebral perfusion in diabetic subjects: a study with technetium-99m-ethyl cysteinate dimer single photon emission computed tomography. Stroke. 2009 Jan;40(1):306-8. 

Osto E, Kouroedov A, Mocharla P, Akhmedov A, Besler C, Rohrer L, von Eckardstein A, Iliceto S, Volpe M, Lüscher TF, Cosentino F. Inhibition of protein kinase Cbeta prevents foam cell formation by reducing scavenger receptor A expression in human macrophages. Circulation. 2008 Nov 18;118(21):2174-82.

Osto E, Matter CM, Kouroedov A, Malinski T, Bachschmid M, Camici GG, Kilic U, Stallmach T, Boren J, Iliceto S, Lüscher TF, Cosentino F. c-Jun N-terminal kinase 2 deficiency protects against hypercholesterolemia-induced endothelial dysfunction and oxidative stress. Circulation. 2008 Nov 11;118(20):2073-80.

Camici GG, Schiavoni M, Francia P, Bachschmid M, Martin-Padura I, Hersberger  M, Tanner FC, Pelicci P, Volpe M, Anversa P, Lüscher TF, Cosentino F. Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5217-22.

Reviews

Eidsmo L,  Martini E. Human Langerhans Cells with Pro-inflammatory Features Relocate within Psoriasis Lesions. Frontiers in immunology 2018 9; 300-

Nylen S,  Eidsmo L. Tissue damage and immunity in cutaneous leishmaniasis. Parasite Immunology 2012 34;12 551-61

Editorial Comments

Eidsmo L, Gerlach C. Heavy Water Shedding Light on Antigen-Specific T Cell Responses. Trends in Immunology 2018 39;3 170-172

Cheuk S,  Eidsmo L. The Skinny on Fat Trm Cells. Immunity 2017 47;6 1012-1014