ULF HEDIN GROUP

Vascular surgery

About

Vascular disease is the leading cause of death and disability in the western world. In order to prevent disease development and develop preventive strategies, a complete understanding of basic cellular and molecular mechanisms is necessary. Our group utilizes a translational platform with advanced cell- and molecular biology, animal models in combination with patient centred research to resolve target processes in peripheral vascular disease such as mechanisms related to thromboembolic carotid disease and stroke, pathogenesis of abdominal aortic aneurysms, vascular repair processes and inflammation in association with interventional procedures and pulmonary hypertension. The close proximity between clinical vascular surgery and advanced molecular research creates a unique platform for the resolution of issues of immediate concern for clinical care as well as breeding of future clinical academic leadership.

 

Research projects

The group is the main research team at the clinical department of vascular surgery at the Karolinska University Hospital and belongs to the Department of Molecular Medicine and Surgery at the Karolinska Institutet. It contains several principal investigators, each with a specific target project, an administrative and technical staff, post-docs, and PhD students. Collaborations are established with the cardiovascular research groups at CMM, the Departments of Clinical Physiology, Neurology, Cardiology, Nuclear Medicine, Clinical Chemistry, and Clinical Pharmacology at the hospital as well as the Departments of Cell and Molecular Biology, Molecular Biochemistry and Biology and SciLifeLab, researchers at Royal School of Technology and at Uppsala University.

 

Abdominal Aortic Aneurysms

Abdominal aortic aneurysms (AAA) are caused by degradation of load bearing components of the vessel wall matrix. Rupture of abdominal aortic aneurysms is the cause the death in 1‐2 % of individuals over 60 years of age. The risk of rupture is related to aneurysm size. The group in collaboration with Per Eriksson's group at the atherosclerosis research unit studies mechanisms contributing to AAA growth with emphasis on proteolytic activity originating in the intraluminal thrombus and cellular sources and mechanisms of proteolytic activity. Gender differences for AAA are also studied by these means in addition to epidemiological methods. In collaboration with the department of solid mechanics at the Royal Institute of Technology imaging methods to predict rupture of AAA based on finite element methods are developed. The research will define mechanism that can be influenced pharmacologically in order to prevent AAA growth and thereby also rupture. Imaging will identify aneurysms that are at risk for rupture. The research will be particularly important when screening for AAA is introduced, which already has occurred in the US, UK and Sweden.

 

Aortic Aneurysms - riskfactors for development, growth and rupture

An aneurysm is a local dilatation of a vessel, it usually continues to dilate and eventually the vessel wall can rupture. The most common arterial aneurysm is the abdominal aortic aneurysm and the prevalence of AAA is especially high in elderly men, 1.5% of 65 year old men have AAA. The pathogenesis of this potential lethal disease is still partly unknown, as well as the contributing causes for growth and rupture. There is a gender paradox in AAA; the prevalence is lower in women, but women have a more complex aneurysm morphology, higher rupture risk and worse outcome at treatment. Our group aim at investigating influential gender differences for AAA patients, some areas of special interest are; vessel wall structure, distribution of risk factors, hereditary patterns, rupture risk and reproductive history.

The difference in occurrence of concurrent aneurysms in women and men with AAA is investigated by prospective examinations of arterial walls in patients suffering from aneurysms, and radiological attempts to improve the understanding of the distribution of the disease in cooperation with radiological expertise. The influence of hereditary patterns on the risk to develop AAA in relatives has been shown in registry-based investigations from our group, further estimations of the true risk are made in collaboration with colleagues at KI at Södersjukhuset and Sunderbyn. The regional aspects on prevalence of the disease are investigated in population based registry studies, as well as analysis on risk factor profiles in different AAA cohorts in several regions in Sweden.

 

Carotid atherosclerosis – from molecule to man

Apart from cardiac embolism, most ischemic strokes occur as a consequence to end-stage atherosclerotic disease. Atherosclerosis leads to formation of plaques in the intima of major arteries with accumulation of lipids, inflammation, fibrosis, cell death and calcification. Stable lesions are generally asymptomatic but when plaques become unstable from enhanced inflammation and proteolysis, destabilization of the fibrous cap may lead to plaque rupture, thrombosis (atherothrombosis), embolism and cerebral ischemia. More than 50% of ischemic strokes are caused by thromboembolism from extracranial vessels, as unstable plaques in the carotid bifurcation. The condition can cause transient ischemic attack (TIA), retinal symptoms (amaurosis fugax) or complete stroke. The significance of this process has been confirmed in studies demonstrating that surgery for carotid stenosis, carotid endarterectomy (CEA), in patients with symptomatic (unstable) lesions prevents stroke. Today, there are no diagnostic methods available to predict or identify plaque rupture and thus to prevent stroke from unstable atherosclerosis. Selection of patients for intervention instead rests on surrogate variables for stroke risk, such as the degree of luminal narrowing by the stenosis. In our unit, approximately 60-70 symptomatic patients undergo CEA annually, >85% within two weeks after index event (national guideline), and with an estimated efficacy of 10 prevented strokes whereas 10-15 asymptomatic patients undergo CEA with less than one prevented stroke estimated.

Work plan

This project is based on current studies utilizing an established biobank (BiKE) of plaque and plasma samples from n>800 patients treated at our clinic, which have been prospectively processed for RNA, DNA, proteomic, in situ and in vitro analyses. The biobank is combined with data of phenotypic information, transcriptomic array profiles and genome wide SNP data. The resource has progressively developed and over the years been extensively utilised to identify gene signatures in atherosclerotic plaque instability. The project is currently being expanded to include large-scale characterization of plasma- and tissue proteins as well as non-coding RNAs (miRs) of human atherosclerosis in correlation to transcriptomic profiles, ultimately aiming at detection of plausible biomarkers for unstable end-stage atherosclerosis. Through established collaborations with international and national resources (SciLife; SCAPIS; Göteborgs Universitet; Stanford; King’s College, London), we are implementing state-of-the-art proteomics (mass spectroscopy and affinity-based) of plasma- and tissue samples from patients with stable- and unstable carotid stenosis, next generation methodology for RNA expression analyses in situ, and pre-operative imaging of patients with new MRI- and ultrasound based technology with the ultimate goal of developing targeted bioimaging for the localization of unstable atherosclerotic lesions. 

Aims

Through the identification of circulating signature molecules (biomarkers) for the unstable atheroma and the development of diagnostic tools for morphological characterization of unstable carotid plaques this project will improve stroke-prevention by:

  1. optimizing risk intervention

  2. improving selection of patients for stroke preventive surgery and

  3. supporting development of plaque-stabilizing drugs

 

Complications in Vascular Surgery

Cardiovascular disease is common and is the predominant cause of illness and death in the Western world. Although surgical care can prevent loss of life or limb, it is also associated with a considerable risk of complications and death. Surgical care and its attendant complications represent a substantial burden of disease worthy of attention from the public health community worldwide. In addition to systemic complications such as myocardial infarction, pulmonary disease, and renal failure after vascular surgery, complications can schematically be divided into three major groups:

• Ischemic complications due to stent and graft thrombosis.
• Bleeding complications and coagulopathy.
• Infectious-related complications such as wound and graft infections.

This research highlights different aspects of complications of thrombosis, bleeding and infection associated with vascular injury and open surgical and endovascular treatment of vascular disease. In vascular surgery a balance between coagulation, anticoagulation and fibrinolysis is required to prevent uncontrolled bleeding or its opposite, severe thrombosis. Antithrombotic therapy following vascular intervention is studied at different levels of the coagulation system. Bleeding and blood transfusion in arterial vascular surgery and its impact on morbidity and mortality are analyzed. The activation of coagulation and inflammation in trauma is studied to identify the clinically significant mechanisms and pathways by which the inflammatory and coagulation pathways are activated immediately following major trauma, how they lead to clinical coagulopathy and transfusion requirements, produce organ injury, and how they affect outcome in terms of organ failure and death.

Postoperative infections associated with cardiovascular surgery, the inflammatory response, and new methods for early diagnosis of infection are studied. This research program includes experimental, epidemiological, and clinical patient studies. The projects are expected to provide increased clinical knowledge that directly can be applied in health care.

 

Studies of the natural course of the vein graft disease

Background 

Cardiovascular disease is the leading cause of global mortality and physical disability. Vein graft (VG) bypass technique is commonly used for reconstruction of coronary and peripheral circulation. Between 30 and 70% of grafts fail within 5 years due to thrombosis, intimal hyperplasia (IH) and superimposed atherogenesis, processes related to the faulty endothelialization and poor endothelial function. These processes are over represented in patients with metabolic syndrome and high inflammatory state such as in subjects with diabetes, leading to the increased number of life-threatening complications. Although direct effects of glucose presumably play a role, indirect effects via stimulation of RAGE by AGEs formed during hyperglycemia are probably of greater importance.

Objectives

To develop new imaging diagnostic tools for assessment of VG endothelialization. To identify specific local hemodynamic forces, which contribute to the VG failure in different arterial beds and various disorders. We aim also to determine mechanisms in delayed vessel wall repair in subjects with diabetes and thereby facilitate development of therapeutic strategies against restenosis and vein graft failure in this promptly increasing group of the patients.

Methods

The project is based on studies of the local hemodynamic forces and natural course of endothelialization and IH utilizing a translational approach that covers experimental studies with surgical and physiological animal models and a novel high-resolution imaging technology. Experimental results are related to human disease utilizing specimens obtained at surgery through comparative gene- and protein expression pattern analysis of vein graft samples. The project involves also ultrasound examinations and clinical surveillance of vein grafts in human.

Significance 

The present study will provide mechanistic insights into the processes of VG failure and contribute to the development of specific and well-timed therapeutic interventions for prevention of the VG disease and therefore reduction of the need for dangerous surgical re-interventions.

 

Vessel wall healing

The project is aimed at unraveling the pathophysiology of healing processes in the vessel wall and is more specifically based on studies of the molecular and cellular mechanisms that regulate the function of smooth muscle cells (SMCs) in atherosclerosis with particular focus on plaque stability and in the formation of intimal hyperplasia in in-stent stenosis, restenosis and vein graft failure. Utilizing a large biobank of human atherectomy samples (BiKE) we speculate if human lesions retrieved at surgery could be used to further examine healing processes in the human atheroma. Clinical observations provide a large body of evidence that a healing process, which ultimately stabilize the lesion and provide protection from recurrent symptoms, follows plaque instability. If mechanisms regulating this process were unraveled, pharmacological approaches to promote plaque healing could be developed and thereby prevent consequences of atherosclerosis and plaque rupture. Current approaches include the identification of biomarkers for plaque instability utilizing the BiKE resource with advanced large scale transcriptomics and proteomics in collaboration with Matthias Uhlén and the HPR (Human Protein Resource) project. Animal models designed for validation of human data in rats and transgenic mice including side projects to develop targeted biomarkers for imaging together with Kenneth Caidahl, KI.

 

Vessel wall signaling

Homeostasis in the vessel wall is maintained by signaling between the different cell types and the matrix and recently also been shown to be affected by the flowing blood, also known as shear stress. Our aim is to identify the critical signaling mechanisms in physiological states and understand how they are affected during vascular injury. In particular, we are focusing on insulin‐like growth factor 1 and shear stress related signaling in smooth muscle cells and their role in vessel wall injury. We aim to identify target critical signaling pathways in order to attenuate atherosclerosis progression and complications for example plaque rupture and improve results after vascular surgery. We use in vitro cell culture models, small animal models and even clinical databases and patient samples to test our hypotheses

 
 

Cardiovascular Research Networks

CVP, CARDIOVASCULAR PROGRAM KI

Cardiovascular diseases arising from atherosclerosis constitute the major causes of morbidity and mortality in Sweden and are expected to be the largest group of lethal diseases globally. However, the atherosclerotic process and its complications remain enigmatic and the opportunities for prevention and therapy are limited. Against this background, we have established an internationally leading Center for Cardiovascular Disease integrating clinical, translational and basic research, education and cardiovascular care.

CVP, Cardiovascular program

KIIM, THE KAROLINSKA INFLAMMATION AND IMMUNOLOGY NETWORK

KiiM, the Karolinska Inflammation and Immunology network, ties researchers in the field of immunology and inflammation at the Karolinska Institute and Karolinska University Hospital together. Our primary activity is to arrange a yearly network retreat, which serves to inspire researchers to find new collaborations within KI and to create a we-feeling among immunologists at KI and the Karolinska University Hospital.

KiiM, Karolinska Inflammation and Immunology Network

KIRCNET - KI RESPIRATION AND CIRCULATION NETWORK

The intention of KIRCNET is to act as a hub for cardiovascular and respiratory biology-related research and to give information and to highlight interesting news and events. The ambition of KIRCNET is to strengthen research within the area of circulation and respiration by stimulating collaboration between research groups and facilitating the relation between clinical and preclinical research areas.

KIRCNET

Theses

Linn Smith

2015-12-11

Thrombolysis in Vascular Surgery, Opponent Lars Lönn

Ya-Ting Chang

2015-06-12

Vascular remodeling in pulmonary hypertension, Opponent Ralph Schermuly

Carl Montán

2015-05-29

Bleeding in Aortic Aneurysm Repair, Opponent Anders Jeppsson

Alireza Daryapeyma

2015-04-24

Health Care Associated Infections in Vascular Surgery, Opponent Maarit Venermo

Chi-Nan Tseng

2015-04-10

Interactions between leukocytes, platelets and the endothelium in vein graft failure, Opponent Klas Österberg

Christina Villard

2014-11-07 

AAA in women - risk factor profile and the aneurysm wall, Opponent Eric Allaire

Anneli Linne

2014-10-17

Improved selective screening for AAA, Opponent Jes Lindholt

 

STAR, Stockholm Aneurysm Research Group

Stockholm Aneurysm Research Group, STAR is a collaborative network for scientists with a specific interest in Aneurysmal disease. The overall aim with the network is to improve our knowledge of the pathogenesis, etiology of the disease, and improve our diagnostic skills by identifying patients at high risk for disease development and of rupture. 

 

STAR research area

STAR is a collaborative network for scientists with a specific interest in Aneurysmal disease.

The overall aim with the network is to improve our knowledge of the pathogenesis, etiology of the disease, and improve our diagnostic skills by identifying patients at high risk for disease development and of rupture. Ruptured aneurysms can have a fatal outcome, when untreated.

We also aim at individualizing the therapeutic options by identifying Patient-specific rupture risk and need for treatment. The network has a translational approach and includes correlations between findings from aortic wall biopsies, clinical characteristics and imaging. The group has a specific interest in rupture and growth of aneurysms, and gender aspects. Registry-based projects are also commonly performed within the networks frame. See figure: 

The scientists in the network work in different locations, universities and institutions.

The principal base of the network is located at Center for Molecular Medicine, at Karolinska Institutet, therefore the webpage is based here. 

 

Meetings and Courses STAR

To be updated

Theses STAR

Scheduled Dissertations and Half time controls in STAR 

Dissertation: Andrii Grytsan 

2016-12-20

Abdominal aortic aneurysm inception and evolution - A computational model,Opponent Prof.dr.in F.N (Frans) van de Vosse

Dissertation: Christina Villard

2014-11-07 

AAA in women - risk factor profile and the aneurysm wall, Opponent Eric Allaire

Dissertation: Anneli Linne

2014-10-17

Improved selective screening for AAA, Opponent Jes Lindholt

 
 

Conferences, meetings and courses

CVR Courses

Cardiovascular Research Program VT17 Course for PhD students 

Vascular Web

Meeting and abstract deadlines

ATVB | PVD 2016 Scientific Sessions

Arteriosclerosis, Thrombosis and Vascular Biology | Peripheral Vascular Disease

5-7 May, 2016 | Nashville, Tennessee, USA

84th EAS Congress

www.eas2016.kenes.com

29 May - 1 June, 2016 | Innsbruck, Austria

ESC Congress

www.escardio.org

27-31 August, 2016 | Rome, Italy

ERS Congress

www.erscongress.org

3-7 September, 2016 | London, United Kingdom

American Heart Association Scientific Sessions

http://professional.heart.org

12-16 November, 2016 | New Orleans, USA

ICI Meeting 2016

Innovations in Cardiovascular Interventions

4-6 December, 2016 | Tel Aviv, Israel

 

News Vascular Surgery

Donation to the research project 'Preventing Stroke'

Professor Ulf Hedin, research group leader for vascular surgery at CMM and MMK, KI, has received a donation of 6 MKr over two years from Tedde Jeansson, Jonas and Robert af Jochnick for the project ’Preventing Stroke’, dedicated to the development of targets for pharmacotherapy and imaging of unstable carotid atherosclerosis.

Dissertation: Helen Sinabulya

Diagnosis, treatment and evaluation of chronic venous disease

2017-06-16 kl 09:00, Rehabsalen S2:01 Norrbacka

Half time seminar Sayid Zommorodi

Title: Abdominal Aortic Aneurysm - uncharted aspects of rupture

2017-05-02 kl 14:00 CMM Lecture Hall L8:00 Karolinska Universitetssjukhuset, Solna

Half time seminar Samuel Röhl

Title: Vascular Remodeling - from experimental research to clinical studies

2017-03-29 kl.14:00 CMM, L8:03

Research grant SLL- Hälsa, Medicin och Teknik 

Ulf Hedin has received, jointly with Professor Christian Gasser at KTH,  SEK 1 600 000 from SLL during the period 2017-2018 for the research project "Personalized Vascular Decisions by image-based biomechanics solutions".

New Postdoc

Malin Stenman

Organizational unit:

Vascular Surgery

E-mail:

malin.stenman@ki.se

 

CSTP grants

Antti Siika has received Clinical Scientist Training Program (CSTP) from KI.

Jesper Swedenborg in Memoriam

Professor Jesper Swedenborg, the former leader of Vascular Surgery at Karolinska, died at the age of 76 on December 2nd, 2016. Jesper Swedenborg in Memoriam

CMM researchers receive EU funding

For the first time at KI, Ulf Hedin and Magnus Bäck have together with Johan Frostegård and Peter Stenvinkel and research groups at University of Maastricht, the Netherlands, and Aachen University, Germany received funding from the European Union’s Horizon 2020 research and innovation programme for Early Stage Researcher (ESR) training within the Marie Skłodowska-Curie Innovative Training Network (ITN). The consortium INTRICARE (International Network for Training on Risks of vascular intimal Calcification And roads to Regression of cardiovascular diseasE’) will train a new generation of scientist that will be excellently skilled to expedite our understanding of vulnerable plaque formation, with a particular focus on micro calcification, and to develop innovative solutions for the early prevention, diagnosis, and treatment of atherosclerosis. The duration of the program is 48 months, consisting of 15 ESR projects intended as collaborative PhD projects within the consortium and aimed at double PhD degrees for the candidates. The INTRICARE programme will start as from March 1, 2017 and PhD positions/ESR projects will open for applications in January 2017. 

For more information about INTRICARE and the Marie Skłodowska-Curie Innovative Training Networks (ITNs), please see:http://ec.europa.eu/mariecurieactions and www.intricare.eu.

Research grant

Totally 924 000 SEK during the period 2017-2018 was granted to Ljubica Perisic Matic from the Heart Lung Foundation for the project entitled "Clinical and experimental studies in search for markers of atherosclerosis: Mechanisms of plaque rupture governed by smooth muscle cells".

KID funding 1 400 000 SEK for a PhD student recruitment was granted to Ulf Hedin, Ljubica Matic and Daniel Ketelhuth for the project "The role of proprotein convertases in control of smooth muscle cell function and vascular disease".

Research grant SLL- Hälsa, Medicin och Teknik 

Ulf Hedin has received, jointly with Professor Christian Gasser at KTH,  SEK 1 600 000 from SLL during the period 2017-2018 for the research project "Personalized Vascular Decisions by image-based biomechanics solutions".

Research grant from the Swedish Heart-Lung Foundation

Rebecka Hultgren has received SEK 1.260.000 (forskarmånader) from the Swedish Heart-Lung Foundation during the period 2017-2018, research project: “Aneurysm disease in women and men - development, growth and risk of rupture”.

Rebecka Hultgren has received SEK 600 000 from the Swedish Heart-Lung Foundation during the period 2017-2018 for the research project: “Aneurysm disease in women and men - development, growth and risk of rupture”.

Half-time seminar Moritz Lindquist Liljeqvist

Title: Predicting and preventing abdominal aortic aneurysm growth and rupture - a translational approach

November 30th, 2016 at 10:15 CMM Lecture Hall L8:00 Karolinska Universitetssjukhuset, Solna

Research grant

Ulf Hedin has received SEK 250 000 from the Mats Kleberg Foundation for research on biomarkers of plaque instability in the carotid artery. 

Half-time seminar Olga Nilsson

Title: Strukturerad utbildningsintervention för patienter med bukaortaaneurysm

Friday 9th September at 13:00, Kärlkirurgiska kliniken A2:01, Karolinska Universitetssjukhuset, Solna

Grants

Linnéa Eriksson has received 360 000 SEK (research months) from the Swedish Heart-Lung Foundation during the period 2016-2017, research project “Improvement of vessel wall healing by glucagonlike peptide-1 after arterial injury and vein grafting in diabetes”.

Ljubica Matic has received 70 000 SEK from Tore Nilsons Stiftelse and 50 000 SEK from Stiftelsen Lars Hiertas Minne for the research project  "Biomarkers after atherosclerotic plaque instability and stroke; Clinic and experimental studies”.

Silvia Aldi has received 200 000 SEK from Åke Wibergs Stiftelse for the research project "Study of new markers in human carotid Plaque” and 20 000 SEK from Stiftelsen Sigurd and Elsa Goljes Minne for the research project "Novel molecular mechanisms of atherosclerotic plaque instability and vessel wall healing".

Ulf Hedin has received 150 000 from Diabetesfonden for the research project “Diabetic vein graft disease”.

New Associate Professor of Vascular Surgery 2015

David Lindström

Organizational unit:

Vascular Surgery

E-mail:

David.Lindstrom@ki.se

 

New PhD Student - October 2015

 

Urszula Rykaczewska

Organizational unit:

Vascular Surgery

E-mail:

urszula.rykaczewska@ki.se

 

Research grant SLL 

Ulf Hedin has received, jointly with Professor Christian Gasser at KTH, SEK 600 000 from SLL for the research project "Personalized Vascular Decisions by image-based biomechanics solutions".

Anton Razuvaev has received SEK 90 000 from Geriatric Diseases at Karolinska Institutet for the research project Diabetic vein graft disease.

Higher Clinical Researchers 2016

Joy Roy has received the Stockholm County Council's grant for Higher Clinical Researchers of SEK 800 000 over two years for the research project "Abdominal Aortic Aneurysm: New mechanisms and prediction of growth and rupture"

Research grant

Ulf Hedin has received SEK 500 000 from the Mats Kleberg Foundation for research on biomarkers of plaque instability in the carotid artery.

New Postdoc

Silvia Aldi has received a position as Assistant Professor in Hedin's group from March 1st

 

Research coordinator

Silvia Aldi

E-mail:

silvia.aldi@ki.se

 

Research grant

Carl-Magnus Wahlgren has received 234.000 SEK from Carnegiestiftelsen

Anton Razuvaev has received 45.000 SEK from Geriatric Diseases at Karolinska Institutet for the research project "Diabetic vein graft disease"

Ljubica Matic has received 45.000 SEK for the research project "Novel molecular mechanisms of atherosclerotic plaque instability and vessel wall healing"

Silvia Aldi has received 45.000 SEK for the research project "Melanoregulin is a new player in human atherosclerotic plaque"

New PhD Student

 

PhD student

Sayid Zommorodi

Organizational unit:

Vascular Surgery

E-mail:

sayid.zommorodi@ki.se

 

New members of the group

Louis Riddez, Martin Sundelöf and Evelyne Zibung Hofman from trauma surgery has now joined our group, Welcome!

KID-Funding autumn 2014

Ulf Hedin has been awarded KID-funding from Karolinska Institutet for a new doctoral student. Title: "Identification and characterization of novel vascular smooth muscle cell markers-in biology and disease".

New PhD Student - December 2014

Moritz Lindquist Liljeqvist

Organizational unit:

Vascular Surgery

E-mail:

moritz.lindquist.liljeqvist@ki.se

 

Research grant from the Swedish Heart-Lung Foundation

Joy Roy has received SEK 1.200.000 (forskarmånader) from the Swedish Heart-Lung Foundation during the period 2015-2016, research project: Abdominal Aortic Aneurysm Growth and Rupture: Novel Mechanisms and Patient-Specific Rupture Risk Prediction.

Joy Roy

Phone:

851779355

Organizational unit:

Vascular Surgery

E-mail:

Joy.Roy@ki.se

 

Research grant from the Swedish Heart-Lung Foundation

Rebecka Hultgren has received SEK 1.200.000 (forskarmånader) from the Swedish Heart-Lung Foundation during the period 2015-2016, research project: Aneurysm disease in women and men - development, growth and risk of rupture.

Rebecka Hultgren

Phone:

+46-(0)8-517 765 96

Organizational unit:

Vascular Surgery

E-mail:

Rebecka.Hultgren@ki.se

 

CSTP Grant

Moritz Lindquist Liljeqvist has received Clinical Scientist Training Programme Grant (CSTP) from KI.

 

Moritz Lindquist Liljeqvist

Organizational unit:

Vascular Surgery

E-mail:

moritz.lindquist.liljeqvist@ki.se

 

New PhD Student - November 2014

Samuel Röhl

Organizational unit:

Vascular Surgery

E-mail:

samuel.rohl@ki.se

 

Research grant from Vetenskapsrådet

Vetenskapsrådet will support the research project "Carotid Atherosclerosis and Stroke: From Man to Molecule - A Systems Biology Strategy to Identify Targets in Unstable Atherosclerosis" with SEK 2.100.000 during the period 2015-2017.

Research grant from the Swedish Heart-Lung Foundation

Ulf Hedin has received SEK 1.800.00 from the Swedish Heart-Lung Foundation for the research project "Carotid Atherosclerosis and Stroke: from Molecule to Man".

ALF grant

Ulf Hedin has received SEK 1.700.000 from the Stockholm County Council, ALF research grant, for the project "Carotid Atherosclerosis and Stroke: From Man to Molecule".

Research grant from KTH/SLL

Ulf Hedin receives, jointly with Professor Christian Gasser at KTH, SEK 750.000 from KTH/SLL for the research project "Personalized Vascular Decisions by image-based biomechanics solutions". 

New Postdoc from August 2014

New PhD Students

 

PhD student

Robert Saxelin

Organizational unit:

Vascular Surgery

E-mail:

robert.saxelin@ki.se

 

PhD student

Sari Hammo

Organizational unit:

Vascular Surgery

E-mail:

sari.hammo@ki.se

 

Research grant

Ulf Hedin has received SEK 1 million from the Mats Kleberg Foundation, and SEK 50 000 from the Signe and Olof Wallenius Foundation for research on biomarkers of plaque instability in the carotid artery.

CSTP

Samuel Röhl has received a Clinical Scientist Training Programme (CSTP) from KI. 

Samuel Röhl

Organizational unit:

Vascular Surgery

E-mail:

samuel.rohl@ki.se

 

SSMF stipend

Perisic Ljubica has been awarded with the SSMF, Swedish Society for Medical Research, stipend for postdoctoral studies dedicated to "Discovery and characterization of biomarkers for unstable atherosclerosis".