PEDER S. OLOFSSON GROUP

 

About

Technology is changing the world and bioelectronic medicine is at the forefront of this technological revolution. The pharmaceutical industry's history is based on therapies that target molecular mechanisms, yet these therapies are expensive, difficult to administer, often toxic, and may be accompanied by lethal side effects. Bioelectronic medicine — the convergence of molecular medicine; neuroscience and biology; and electronics and computing to develop cures — may change the future of therapies for a wide variety of diseases. This groundbreaking discipline is aimed at interfacing electronics with nerves to specifically target the biological processes underlying disease. Bioelectronic medicine is now at the epicenter of where healthcare, technology, and science converge. A unique moment exists to characterize the challenges and opportunities facing the future of this scientific domain. 

 

Selected Publications

Bruck E, Lasselin J, The HICUS Study Group, Andersson U, Sackey PV, Olofsson PS. Prolonged elevation of plasma HMGB1 is associated with cognitive impairment in intensive care unit survivorsIntensive Care Med 2020 46:811–812.

Malin SG, Shavva V, Tarnawski L, Olofsson PS. Functions of acetylcholine-producing lymphocytes in immunobiology. Curr Opin Neurobiol. 2020 Jun;62:115-121.

Caravaca AS, Centa M, Gallina AL, Tarnawski L, Olofsson PS. Neural control of vascular inflammation. Bioelectron Med. 2020 Jan 31;6:3.

Peleli M, Ferreira DMS, Tarnawski L, McCann Haworth S, Xuechen L, Zhuge Z, et al. Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status. Redox Biol 2020 Jan;28:101387.

Caravaca AS, Gallina AL, Tarnawski L, Tracey KJ, Pavlov VA, Levine YA, et al. An Effective Method for Acute Vagus Nerve Stimulation in Experimental Inflammation. Front Neurosci 2019 ;13():877.

Olofsson PS, Bouton C. Bioelectronic medicine: an unexpected path to new therapies. J. Intern. Med. 2019 Sep;286(3):237-239

Eberhardson M, Tarnawski L, Centa M, Olofsson PS.  Neural Control of Inflammation: Bioelectronic Medicine in Treatment of Chronic Inflammatory Disease. Cold Spring Harb Perspect Med 2019 Jul;():

Brück E, Larsson JW, Lasselin J, Bottai M, Hirvikoski T, Sundman E, et al. Lack of clinically relevant correlation between subjective and objective cognitive function in ICU survivors: a prospective 12-month follow-up study. Crit Care 2019 07;23(1):253

Libby P, Buring JE, Badimon L, Hansson GK, Deanfield J, Bittencourt MS, et al. Atherosclerosis. Nat Rev Dis Primers 2019 Aug;5(1):56

Jiang X, Wang F, Wang Y, Gisterå A, Roy J, Paulsson-Berne G, et al. Inflammasome-Driven Interleukin-1α and Interleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity. JACC Basic Transl Sci 2019 Jun;4(3):304-317

Centa M, Ketelhuth DFJ, Malin S, Gisterå A. Quantification of Atherosclerosis in Mice. J Vis Exp 2019 Jun;(148):

Lehner KR, Silverman HA, Addorisio ME, Roy A, Al-Onaizi MA, Levine Y, et al. Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation. Front Immunol 2019 ;10:585

Christersdottir T, Pirault J, Gisterå A, Bergman O, Gallina AL, Baumgartner R, et al. Prevention of radiotherapy-induced arterial inflammation by interleukin-1 blockade. Eur. Heart J. 2019 Aug;40(30):2495-2503

Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R, et al. Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability. Circulation 2019 May;139(21):2466-2482

Cox MA, Duncan GS, Lin GHY, Steinberg BE, Yu LX, Brenner D, et al. Choline acetyltransferase-expressing T cells are required to control chronic viral infection. Science 2019 02;363(6427):639-644

Eberhardson M, Hedin CRH, Carlson M, Tarnawski L, Levine YA, Olofsson PS. Towards improved control of inflammatory bowel disease. Scand. J. Immunol. 2019 Mar;89(3):e12745

Hansson GK. Inflammation, protection, and the problems of translation. Nat Rev Cardiol 2018 Dec;15(12):729-730

Tarnawski L, Reardon C, Caravaca AS, Rosas-Ballina M, Tusche MW, Drake AR, et al. Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex. Front Immunol 2018 ;9():2648

Gisterå A, Klement ML, Polyzos KA, Mailer RKW, Duhlin A, Karlsson MCI, et al. Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice. Circulation 2018 Nov;138(22):2513-2526

Centa M, Prokopec KE, Garimella MG, Habir K, Hofste L, Stark JM, et al. Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis. Arterioscler Thromb Vasc Biol 2018 Aug;38(8):e145-e158

Söderström LÅ, Tarnawski L, Olofsson PS. CD137: A checkpoint regulator involved in atherosclerosis. Atherosclerosis 2018 May;272:66-72

Forteza MJ, Polyzos KA, Baumgartner R, Suur BE, Mussbacher M, Johansson DK, et al. Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice. Front Immunol 2018;9:950

Laguna-Fernandez A, Checa A, Carracedo M, Artiach G, Petri MH, Baumgartner R, et al. ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages. Circulation 2018 Oct;138(16):1693-1705

Zaghloul N, Addorisio ME, Silverman HA, Patel HL, Valdés-Ferrer SI, Ayasolla KR, et al. Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors. Front Immunol 2017 ;8:1673

Söderström LÅ, Jin H, Caravaca AS, Klement ML, Li Y, Gisterå A, et al. Increased Carotid Artery Lesion Inflammation Upon Treatment With the CD137 Agonistic Antibody 2ACirc. J. 2017 Nov;81(12):1945-1952

Mailer RKW, Gisterå A, Polyzos KA, Ketelhuth DFJ, Hansson GK. Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population. Sci Rep 2017 Nov;7(1):15655

Consolim-Colombo FM, Sangaleti CT, Costa FO, Morais TL, Lopes HF, Motta JM, et al. Galantamine alleviates inflammation and insulin resistance in patients with metabolic syndrome in a randomized trial. JCI Insight 2017 Jul;2(14):

Yang T, Zhang XM, Tarnawski L, Peleli M, Zhuge Z, Terrando N, et al. Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. Redox Biol 2017 10;13:320-330

Olofsson PS, Tracey KJ. Bioelectronic medicine: technology targeting molecular mechanisms for therapy. J Intern Med 2017 07;282(1):3-4

French JA, Koepp M, Naegelin Y, Vigevano F, Auvin S, Rho JM, et al. Clinical studies and anti-inflammatory mechanisms of treatments. Epilepsia 2017 07;58 Suppl 3:69-82

Caravaca AS, Tsaava T, Goldman L, Silverman H, Riggott G, Chavan SS, et al. A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve. J Neural Eng 2017 12;14(6):066005

Olofsson PS, Steinberg BE, Sobbi R, Cox MA, Ahmed MN, Oswald M, et al. Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase. Nat Biotechnol 2016 Oct;34(10):1066-1071

Caravaca AS, Tsaava T, Goldman L, Silverman H, Riggott G, Chavan SS, et al. A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve. J Neural Eng 2017 12;14(6):066005

Hudson LK, Dancho ME, Li J, Bruchfeld JB, Ragab AA, He MM, et al. Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice. Mol Med 2016 Oct;22:585-596

Yang H, Wang H, Levine YA, Gunasekaran MK, Wang Y, Addorisio M, et al. Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes. JCI Insight ;1(7):

Steinberg BE, Sundman E, Terrando N, Eriksson LI, Olofsson PS. Neural Control of Inflammation: Implications for Perioperative and Critical Care. Anesthesiology 2016 May;124(5):1174-89