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Translational Neuropharmacology


Parkinson´s disease and depression are common disorders with largely unknown etiologies. There is a need for disease-modifying therapies in these disease states. The Section of Translational Neuropharmacology studies these disease states at a molecular and cellular level both in preclinical models and in specimens from patients. The goal is to identify novel targets for improved diagnostics and pharmacological receptor-based treatments. It is important for receptors to be properly located in nerve cell to properly activate relevant intracellular signaling cascades. The laboratory studies the dynamics of the localization and functionality of receptors. A working hypothesis is that altered levels of receptors in a certain compartment of a nerve cell can underlie pathology. In that respect experiments are focused on identifying and study adaptor proteins and lipids which bind to receptors and regulate their localization and function. Biochemical, histological, pharmacological, molecular biological and behavioral techniques are being used in the laboratory.


Selected publications

Eriksson T, Delagrange P, Spedding M, Popoli M, Mathé A, Ögren S, et al. Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration. Mol. Psychiatry 2012 Feb;17(2):173-84.

Madeira A, Ohman E, Nilsson A, Sjögren B, Andrén P, Svenningsson P. Coupling surface plasmon resonance to mass spectrometry to discover novel protein-protein interactions. Nat Protoc 2009 ;4(7):1023-37.

Zhang X, Andren P, Greengard P, Svenningsson P. Evidence for a role of the 5-HT1B receptor and its adaptor protein, p11, in L-DOPA treatment of an animal model of Parkinsonism. Proc. Natl. Acad. Sci. U.S.A. 2008 Feb;105(6):2163-8.

Svenningsson P, Chergui K, Rachleff I, Flajolet M, Zhang X, El Yacoubi M, et al. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 2006 Jan;311(5757):77-80.

Svenningsson P, Tzavara E, Carruthers R, Rachleff I, Wattler S, Nehls M, et al. Diverse psychotomimetics act through a common signaling pathway. Science 2003 Nov;302(5649):1412-5.

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