Biography
Professor Robert A. Harris
Professor Robert A. Harris (Bob) was born in Harpenden in Southern UK in 1966. He conducted a Bsc.Hons undergraduate degree at Portsmouth Polytechnic, majoring in Parasitology in 1987. PhD studies at University College London studying innate immune agglutinins in Schistosoma host snail species with Terry Preston and Vaughan Southgate as supervisors culminated with a thesis defence in early 1991. A 2.5 year postdoc at the London School of Hygiene & Tropical Medicine in Paul Kaye’s research group ensued, with focus on understanding the intracellular fate of Leishmania spp. protozoans in macrophages. Bob was awarded a Wellcome Trust postdoctoral fellowship that permitted his relocation to the Karolinska Institutet (Stockholm, Sweden) in the spring of 1994. A postdoc period was spent split between the labs of Anders Örn and Tomas Olsson, in which he studied Trypanosoma cruzi and Trypanosoma bruceii protozoan proteins. Bob became an Associate Professor at the Karolinska Institutet in 1999, heralding his establishment as a PI. Bob started to work with autoimmune diseases in 1996 and began study of therapy using live parasite infections or parasite molecules. His research group has developed autoantigen-specific vaccines, defined the effects of post-translational biochemical molecules on autoantigenicity and developed a macrophage adoptive transfer therapy that prevents pathogenesis in several experimental disease models. He became Professor of Immunotherapy in Neurological Diseases in 2013. In recent years research focus has centred on understanding the immunopathogenesis of incurable neurodegenerative diseases, with particular emphasis on development of immunotherapies directed at microglial cells as potential therapeutic paradigms.
Bob Harris CV July 2020
ERIK HERLENIUS GROUP
Development of autonomic control
About
Immature or deficient autonomic control is a common problem in infants born at a premature age and is of central importance in apneas, secondary hypoxic brain damage and sudden infant death syndrome.
PER ERIKSSON GROUP
Research
For better understanding of disturbances in respiratory control we study early development of cardiorespiratory control, brainstem neural networks and its associations with normal and pathological breathing. The conceptual change introduced by our recent data that endogenous prostaglandins are central pathogenic factors in respiratory disorders and the hypoxic response, open new diagnostic and therapeutic avenues that should significantly better the diagnostics and treatment of newborns and adult patients.
Inflammation is a major culprit in breathing disorders and we hypothesize that by using a newly developed urinary prostaglandin biomarker we can screen, detect and protect against inflammation related breathing disorders.
Our collaborative efforts enable us to move from a clinical problem to molecular understanding of the disease and studies are performed in patients, animal & in vitro models.
Our research is focused on the development of autonomic control with normal and paediatric patients as the target. Autonomic dysfunction in breathing and circulatory control often has its origin in neurodevelopment disorders. Furthermore, our basic research in developmental neuroscience how neural activity and stem cells form activity dependent networks is vital for the development of therapeutic interventions.
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Contact: communication@cmm.se
CENTER FOR MOLECULAR MEDICINE
PIOTR RELIGA TEAM
About
Aim of our research is to find functional mechanism of changes in morphological structure of blood vessels that can be used for diagnosis and treatment of common diseases.
The diseases such as ischemia and cancer are related to pathological state of arteries. The pathogens, blood flow and interaction with surrounding tissues lead to stimuli of the cells in the vessels and morphological changes. The process is triggered by cytokines, chemokines and adhesion molecules on the cellular surface. This turn results in recruitment of monocytes, and lymphocytes than infiltrate the blood vessel wall and surrounding tissues. In the large vessels stimulation of smooth muscle cells and surrounding adventitia leads to migration of the cells towards the blood vessels lumen. The following thickening of vascular wall leads to blood flow disturbances and ischemia. In cancer, most tumor vessels do not fit into the conventional hierarchy of arterioles, capillaries and venules. Abnormalities involve all components of the vascular wall: endothelial cells, mural cells and basement membrane. The changes in the vascular morphology are related to formation of metastasis.
We use cutting-edge methodology, detailed molecular studies on human tissues and animal models for studies of vascular mechanisms of diseases. We use the following techniques that are uniquely related to our research.
• Photonic methods that allow a contact and marker-free identification and selection of cells (RAMAN microscopy)
• Magnetic cell select devices that capture and transport cells through the circulatory system
• Tracer imaging technologies to monitor anatomic structure AND demonstrating cellular function using magnetic resonance imaging (MRI) and a new imaging technology known as magnetic particle imaging (MPI).